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Tissue engineering is the best approach for periodontal regeneration, which utilizes a triad of stem cells, signalling molecules and scaffold. Among the signalling molecules platelet derived growth factor (PDGF) is most commonly used growth factor for regeneration of periodontal defects. Need of a suitable scaffold is must so as to provide support to the signalling molecule, one such scaffold is beta tricalcium phosphate. The present study and review provides the comprehensive data regarding the use of growth factors along with various scaffolds for periodontal regeneration.