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Development new technologies and researches are considered as a vital strategic source and they will not add value to the countries economics unless they become commercialized. So selecting a suitable commercialization strategy is considered as a strategic selection and accordingly the importance of the factors affecting this selection is more obvious. In this study, using a mix method, as well as applying agency theory; firstly, the local Factors Affecting the Selection of Iran special commercialization strategy in 41 young biotechnology companies were identified through interview and then a questionnaire was prepared integrating these factors and the factors extracted from the existing literature and was distributed among a larger sample in order to obtain the integrity. Finally, after analyzing the questionnaires, the factors affecting the selection of each introduced commercialization strategy were identified.